Evaluating Rapid Application Development with Python for Heterogeneous Processor-based FPGAs

As modern FPGAs evolve to include more het- erogeneous processing elements, such as ARM cores, it makes sense to consider these devices as processors first and FPGA accelerators second. As such, the conventional FPGA develop- ment environment must also adapt to support more software- like programming functionality. While high-level synthesis tools can help reduce FPGA development time, there still remains a large expertise gap in order to realize highly performing implementations. At a system-level the skill set necessary to integrate multiple custom IP hardware cores, interconnects, memory interfaces, and now heterogeneous processing elements is complex. Rather than drive FPGA development from the hardware up, we consider the impact of leveraging Python to ac- celerate application development. Python offers highly optimized libraries from an incredibly large developer community, yet is limited to the performance of the hardware system. In this work we evaluate the impact of using PYNQ, a Python development environment for application development on the Xilinx Zynq devices, the performance implications, and bottlenecks associated with it. We compare our results against existing C-based and hand-coded implementations to better understand if Python can be the glue that binds together software and hardware developers.Comment: To appear in 2017 IEEE 25th Annual International Symposium on Field-Programmable Custom Computing Machines (FCCM'17

Somatografías en los Dubliners de James Joyce

“Somatografías en los Dubliners de James Joyce” trae a la delantera un recurso para leer algunas literaturas del cuerpo, un mundo narrativo que implica un medio para imaginar y visualizar los cuerpos de los personajes. Los Dubliners nos lleva por un recorrido que nos permite corroborar las representaciones de cambios físicos en cada uno de los individuos en el texto. Esta lectura corporal activa un vínculo íntimo entre lectores y personajes. Una cartografía de los protagonistas no sólo ubica a los personajes en el texto sino que los aproxima a nuestras percepciones

Leonora Carrington/Lucy Skaer

The output is a curated exhibition and catalogue of Viktor Wynd's impressive collection of Leonora Carrington artworks.This collection is macabre as it is unique, bringing together little-known prints and drawings which detail the surrealist bestiary of Carrington’s imaginative universe (explored further by Marina Warner), as well as four early canvases from Carrington’s pre-surrealist period (analysed in- depth by Susan L. Aberth). An anecdote by Wynd and short story by Carrington’s son, Gabriel Weisz, further nuance the visual narratives under consideration. Until this exhibition, the collection had never been shown together. Leeds Arts University hosted the collection as a major part of its Leonora Carrington/Lucy Skaer research exhibition (15 July – 2 September 2016). The artworks included in the catalogue toured subsequently to The Viktor Wynd Museum in London. Special thanks go to Viktor Wynd for his enthusiasm, generosity and support in realising the exhibition as well as Susan L. Aberth, Gabriel Weisz Carrington, and Marina Warner for their erudite contributions to the catalogue. The photography is by Chris Renton and the catalogue has been designed by D&M Heritage Ltd. Further grateful thanks and acknowledgement to: Chloe Aridjis, Jonathan P. Eburne, Sean Kissane, Lynn Lu, Steve Lucas, Wendi Norris, Jeffrey Sherwin, Lucy Skaer, Samantha Sweeting, and colleagues at Leeds College of Art

Incidence, Patterns, and Associations Between Dual-Antiplatelet Therapy Cessation and Risk for Adverse Events Among Patients With and Without Diabetes Mellitus Receiving Drug-Eluting Stents: Results From the PARIS Registry.

OBJECTIVES: The aim of this study was to examine the frequency and clinical impact of different cessation patterns of dual-antiplatelet therapy (DAPT) after percutaneous coronary intervention with drug-eluting stents among patients with and those without diabetes mellitus (DM). BACKGROUND: Early DAPT suspension after percutaneous coronary intervention increases the risk for major adverse cardiac events. However, temporal variability in risk and relation to DAPT cessation patterns among patients with DM remain unclear. METHODS: Using data from the PARIS (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients) registry, 1,430 patients with DM (34%) and 2,777 without DM (66%) treated with drug-eluting stents were identified. DAPT cessation modes were classified as temporary interruption (<14 days), disruption because of bleeding or poor compliance, and physician-recommended discontinuation. RESULTS: During 2-year follow-up, DM was associated with an increased risk for thrombotic events but a similar risk for bleeding. The cumulative incidence of DAPT cessation was significantly lower in patients with versus those without DM (50.1% vs. 55.4%; p < 0.01), driven largely by less frequent physician-guided discontinuation beyond 1 year. In contrast, 2-year rates of interruption and disruption were similar between groups. When DAPT was interrupted or discontinued under physician guidance, the risk for major adverse cardiac events was unchanged compared with patients with DM on uninterrupted DAPT. Conversely, when DAPT was disrupted, the risk for major adverse cardiac events increased compared with uninterrupted DAPT, regardless of diabetic status, with no evidence of statistical interaction. CONCLUSIONS: DAPT cessation patterns vary according to diabetic status, with less frequent physician-guided discontinuation among patients with DM. The presence of DM does not emerge as a modifier of cardiovascular risk after DAPT cessation

Causes, Timing, and Impact of Dual Antiplatelet Therapy Interruption for Surgery (From the PARIS Registry)

Temporary interruption of dual antiplatelet therapy (DAPT) is not infrequently required in patients undergoing percutaneous coronary intervention (PCI). We sought to describe the procedures and outcomes associated with DAPT interruption in patients treated with DAPT following successful PCI from the Patterns of non-adherence to anti-platelet regimens in stented patients registry (n = 5018). DAPT interruption was prespecified as physician recommended cessation forcohort, 490 patients (9.8%) experienced 594 DAPT interruptions over 2 years following PCI. Only 1 antiplatelet agent was interrupted in 57.2% cases and interruption was frequently recommended by noncardiologists (51.3%). Where type of surgery was reported, majority of DAPT interruptions occurred for minor surgery (68.4% vs 31.6%) and a similar cessation pattern of single versus dual antiplatelet cessation was observed regardless of minor or major surgery. Subsequent to DAPT interruption, 12 patients (2.4%) experienced 1 thrombotic event each, of which 5 (1.0%) occurred during the interruption period. All events occurred in patients who either stopped both agents (8 of 12) or clopidogrel-only (4 of 12), with no events occurring due to aspirin cessation alone. In conclusion, in the Patterns of Non-adherence to Anti-platelet Regiments in Stented Patients registry, 1 in 10 patients were recommended DAPT interruption for surgery within 2 years of PCI. Interruption was more common for a single agent rather than both antiplatelet agents regardless of severity of surgery, and was frequently recommended by noncardiologists. Only 1% of patients with DAPT interruption experienced a subsequent thrombotic event during the interruption period, which mainly occurred in patients stopping both antiplatelet agents

Dual-Antiplatelet Therapy Cessation and Cardiovascular Risk in Relation to Age: Analysis From the PARIS Registry.

OBJECTIVES: The aim of this study was to examine the association between dual-antiplatelet therapy (DAPT) cessation and cardiovascular risk after percutaneous coronary intervention in relation to age. BACKGROUND: Examination of outcomes by age after percutaneous coronary intervention is relevant given the aging population. METHODS: Two-year clinical outcomes, incidence, and effect of DAPT cessation on outcomes were compared by ages ≤55, 56 to 74, and ≥75 years from the PARIS (Patterns of Non-Adherence to Antiplatelet Regimens in Stented Patients) registry. DAPT cessation included physician-recommended discontinuation, interruption for surgery, and disruption (from noncompliance or bleeding). Clinical endpoints were major adverse cardiac events (MACE) (a composite of cardiac death, definite or probable stent thrombosis, spontaneous myocardial infarction, or clinically indicated target lesion revascularization), a secondary restrictive definition of MACE (MACE2) excluding target lesion revascularization, and bleeding. RESULTS: A total of 1,192 patients (24%) were ≤55 years, 2,869 (57%) were 56 to 74 years, and 957 (19%) were ≥75 years of age. Patients ≥75 years of age had higher DAPT cessation rates and increased risk for MACE2, death, cardiac death, and bleeding compared with younger patients. Discontinuation and interruption were not associated with increased cardiovascular risk across age groups, whereas disruption was associated with increased risk for MACE and MACE2 in younger patients but not in patients ≥75 years of age (p for trend <0.05). CONCLUSIONS: Nonadherence and outcomes vary by age, with patients ≥75 years having the highest DAPT cessation rates. We observed no association between outcomes and DAPT cessation in patients ≥75 years, whereas discontinuation was associated with lower MACE rates and disruption with increased MACE rates in patients <75 years

Meat consumption does not explain differences in household food carbon footprints in Japan

Many studies, including the EAT-Lancet Commission report, have argued that changing diets—in particular, shifting away from beef in favor of white meat and vegetables—can substantially reduce household carbon footprints (CFs). This argument implies that households with high CFs consume more meat than low-CF households. An observation of diet and CF across 60,000 households in Japan, a nation whose diet and demographics are in many ways globally indicative, does not support this. Meat consumption only weakly explains the difference between high- and low-CF households and is not localized to any particularly easily targeted group. We find that while nearly all households can reduce their CF by eating less meat, higher-CF households are not distinguished by excessive meat consumption relative to other households but rather have higher household CF intensity because of elevated consumption in other areas including restaurants, confectionery, and alcohol

Ticagrelor with or without Aspirin in High-Risk Patients after PCI.

BACKGROUND: Monotherapy with a P2Y12 inhibitor after a minimum period of dual antiplatelet therapy is an emerging approach to reduce the risk of bleeding after percutaneous coronary intervention (PCI). METHODS: In a double-blind trial, we examined the effect of ticagrelor alone as compared with ticagrelor plus aspirin with regard to clinically relevant bleeding among patients who were at high risk for bleeding or an ischemic event and had undergone PCI. After 3 months of treatment with ticagrelor plus aspirin, patients who had not had a major bleeding event or ischemic event continued to take ticagrelor and were randomly assigned to receive aspirin or placebo for 1 year. The primary end point was Bleeding Academic Research Consortium (BARC) type 2, 3, or 5 bleeding. We also evaluated the composite end point of death from any cause, nonfatal myocardial infarction, or nonfatal stroke, using a noninferiority hypothesis with an absolute margin of 1.6 percentage points. RESULTS: We enrolled 9006 patients, and 7119 underwent randomization after 3 months. Between randomization and 1 year, the incidence of the primary end point was 4.0% among patients randomly assigned to receive ticagrelor plus placebo and 7.1% among patients assigned to receive ticagrelor plus aspirin (hazard ratio, 0.56; 95% confidence interval [CI], 0.45 to 0.68; P<0.001). The difference in risk between the groups was similar for BARC type 3 or 5 bleeding (incidence, 1.0% among patients receiving ticagrelor plus placebo and 2.0% among patients receiving ticagrelor plus aspirin; hazard ratio, 0.49; 95% CI, 0.33 to 0.74). The incidence of death from any cause, nonfatal myocardial infarction, or nonfatal stroke was 3.9% in both groups (difference, -0.06 percentage points; 95% CI, -0.97 to 0.84; hazard ratio, 0.99; 95% CI, 0.78 to 1.25; P<0.001 for noninferiority). CONCLUSIONS: Among high-risk patients who underwent PCI and completed 3 months of dual antiplatelet therapy, ticagrelor monotherapy was associated with a lower incidence of clinically relevant bleeding than ticagrelor plus aspirin, with no higher risk of death, myocardial infarction, or stroke. (Funded by AstraZeneca; TWILIGHT ClinicalTrials.gov number, NCT02270242.)

BEASTS OF THE SOUTHERN WILD: DISCOVERY OF NINE ULTRA FAINT SATELLITES IN THE VICINITY OF THE MAGELLANIC CLOUDS

We have used the publicly released Dark Energy Survey data to hunt for new satellites of the Milky Way in the Southern hemisphere. Our search yielded a large number of promising candidates. In this paper, we announce the discovery of 9 new unambiguous ultra-faint objects, whose authenticity can be established with the DES data alone. Based on the morphological properties, three of the new satellites are dwarf galaxies, one of which is located at the very outskirts of the Milky Way, at a distance of 380 kpc. The remaining 6 objects have sizes and luminosities comparable to the Segue~1 satellite and can not be classified straightforwardly without follow-up spectroscopic observations. The satellites we have discovered cluster around the LMC and the SMC. We show that such spatial distribution is unlikely under the assumption of isotropy, and, therefore, conclude that at least some of the new satellites must have been associated with the Magellanic Clouds in the past.Comment: Accepted to ApJ; See also 1503.02584; Changes w.r.t. v2: the discussion section updated slightly; small changes in the table with satellite parameter

Shifts of Gamma Phase across Primary Visual Cortical Sites Reflect Dynamic Stimulus-Modulated Information Transfer

Distributed neural processing likely entails the capability of networks to reconfigure dynamically the directionality and strength of their functional connections. Yet, the neural mechanisms that may allow such dynamic routing of the information flow are not yet fully understood. We investigated the role of gamma band (50–80 Hz) oscillations in transient modulations of communication among neural populations by using measures of direction-specific causal information transfer. We found that the local phase of gamma-band rhythmic activity exerted a stimulus-modulated and spatially-asymmetric directed effect on the firing rate of spatially separated populations within the primary visual cortex. The relationships between gamma phases at different sites (phase shifts) could be described as a stimulus-modulated gamma-band wave propagating along the spatial directions with the largest information transfer. We observed transient stimulus-related changes in the spatial configuration of phases (compatible with changes in direction of gamma wave propagation) accompanied by a relative increase of the amount of information flowing along the instantaneous direction of the gamma wave. These effects were specific to the gamma-band and suggest that the time-varying relationships between gamma phases at different locations mark, and possibly causally mediate, the dynamic reconfiguration of functional connections